What are symptoms of Wegener's granulomatosis?The disorder usually develops over 4 to 12 months, with 90 percent of patients presenting with upper or lower respiratory tract symptoms, or both. Common symptoms and signs are pain in the sinuses and ears; nasal congestion and discharge and nosebleeds. Other early symptoms include fever, fatigue, loss of appetite, weight loss, pain in the joints and muscles,
skin rash, and redness and swelling in the eyes. Other problems that may occur include a chronic cough (sometimes coughing up blood), breathing difficulties, skin ulcers, and weakness and numbness in the limbs.
The disease may begin suddenly or gradually. Symptoms typically appear first in the upper respiratory tract—the ears, nose, sinuses and trachea. At first, these symptoms may mimic a cold, with runny nose, cough and sore throat, but they can become worse and progress to pneumonia. Patients also may have frequent and severe nosebleeds, ear infections, sinus infections and a chronic cough, and may even cough up blood. Other symptoms include fever, joint pain, loss of appetite, anemia, general weakness and fatigue. Some patients develop sores on the skin.
Almost all patients with this disease have problems such as congestion of the nose, ear infections, sinus infections, or they develop large gums. Many also develop coughs, have trouble breathing, or they cough-up blood. Fever, night sweats, sores, or ulcers may form around the nostrils, while granulomas may block the nasal passages. Other symptoms include one eye protruding out, Bruising, and joint pain. This disease will eventually affect the kidneys of most patients, and can very quickly cause kidney failure. Some patients may notice blood in their urine. Some patients will have a "saddle" shaped nose due to the disease destroying parts of the nose.